NK1 RA
Medical abbreviation · Drug Class
| Stands for | Neurokinin-1 receptor antagonist |
|---|---|
| Categories | Medical |
NK1 RA stands for Neurokinin-1 receptor antagonist, a drug class abbreviation.
Antiemetics, including aprepitant, fosaprepitant, rolapitant and netupitant, that block substance P at NK1 receptors. They are added to a 5-HT3 antagonist and dexamethasone to prevent nausea from highly emetogenic chemotherapy such as cisplatin.
Example: Cisplatin day 1: fosaprepitant 150 mg IV (NK1 RA), ondansetron, dexamethasone.
Usage notes
Aprepitant (Emend), approved in 2003, was the first in class and is especially effective against delayed nausea occurring days after treatment. It inhibits CYP3A4, so dexamethasone doses are reduced when combined. NK1 antagonists also prevent postoperative nausea.
Related abbreviations
More drug class abbreviations
- MHT – Menopausal hormone therapy
- MRA – Mineralocorticoid receptor antagonist
- mTORi – Mammalian target of rapamycin inhibitor
- NAI – Neuraminidase inhibitor
- NaSSA – Noradrenergic and specific serotonergic antidepressant
- NDRI – Norepinephrine-dopamine reuptake inhibitor
- NNRTI – Non-nucleoside reverse transcriptase inhibitor
- NOAC – Novel oral anticoagulant
- NRT – Nicotine replacement therapy
- NRTI – Nucleoside/nucleotide reverse transcriptase inhibitor
- NSAID – Nonsteroidal anti-inflammatory drug
- OAC – Oral anticoagulant
See all 113 drug class abbreviations →
This entry is for general education and is not medical advice. Abbreviation use varies between institutions; always confirm in context.