MACE
Medical abbreviation · Cardiology
| Stands for | Major adverse cardiovascular events |
|---|---|
| Categories | Medical |
MACE stands for Major adverse cardiovascular events, a cardiology abbreviation.
Composite end point in cardiology trials that typically combines cardiovascular death, nonfatal heart attack and nonfatal stroke, sometimes adding hospitalization or urgent revascularization. Regulators use it to judge whether drugs such as diabetes treatments are safe for the heart.
Example: The trial's primary end point, three-point MACE, occurred in 8.1 percent of the drug group.
Usage notes
"Three-point MACE" refers to the classic trio of cardiovascular death, MI and stroke. Definitions vary between studies, which complicates comparisons, and the term is sometimes expanded as major adverse cardiac events. FDA guidance from 2008 required new diabetes drugs to exclude excess cardiovascular risk, which made large MACE outcome trials common.
Related abbreviations
More cardiology abbreviations
- LV – Left ventricle
- LVAD – Left ventricular assist device
- LVEDP – Left ventricular end-diastolic pressure
- LVEF – Left ventricular ejection fraction
- LVH – Left ventricular hypertrophy
- LVOT – Left ventricular outflow tract
- MAP – Mean arterial pressure
- MAT – Multifocal atrial tachycardia
- METs – Metabolic equivalents
- MI – Myocardial infarction
- MINOCA – Myocardial infarction with nonobstructive coronary arteries
- MPI – Myocardial perfusion imaging
See all 229 cardiology abbreviations →
This entry is for general education and is not medical advice. Abbreviation use varies between institutions; always confirm in context.