DAA

Medical abbreviation · Infectious Disease

DAA
Stands forDirect-acting antiviral
CategoriesMedical

DAA stands for Direct-acting antiviral, an infectious disease abbreviation.

Class of oral hepatitis C drugs that block specific viral proteins (NS3/4A protease, NS5A or NS5B polymerase), curing most infections with few side effects. Pangenotypic combinations such as glecaprevir/pibrentasvir and sofosbuvir/velpatasvir treat all genotypes.

Example: Treatment-naive HCV without cirrhosis; DAA course of glecaprevir/pibrentasvir for 8 weeks.

Usage notes

Sofosbuvir's approval in 2013 began the DAA era, replacing interferon-based regimens that caused severe side effects and cured far fewer people. High prices initially led insurers to restrict access. Hepatitis B can reactivate during DAA therapy, so patients are screened first. The term is also used for some newer influenza and COVID-19 antivirals.

More infectious disease abbreviations

  • CDI – Clostridioides difficile infection
  • CMV – Cytomegalovirus
  • COVID-19 – Coronavirus disease 2019
  • CRAB – Carbapenem-resistant Acinetobacter baumannii
  • CRE – Carbapenem-resistant Enterobacterales
  • CT – Chlamydia trachomatis
  • DOT – Directly observed therapy
  • E. coli – Escherichia coli
  • EBV – Epstein-Barr virus
  • EPT – Expedited partner therapy
  • ESBL – Extended-spectrum beta-lactamase
  • FUO – Fever of unknown origin

See all 92 infectious disease abbreviations →

Edited by the AbbreviationList.com team. Spotted an error or a missing meaning? Contact us.

This entry is for general education and is not medical advice. Abbreviation use varies between institutions; always confirm in context.