INSTI
Medical abbreviation · Drug Class
| Stands for | Integrase strand transfer inhibitor |
|---|---|
| Categories | Medical |
INSTI stands for Integrase strand transfer inhibitor, a drug class abbreviation.
HIV drugs that block integrase, the enzyme that inserts viral DNA into human chromosomes: raltegravir, elvitegravir, dolutegravir, bictegravir and cabotegravir. INSTI-based regimens are preferred initial therapy in most guidelines.
Example: Initial ART: INSTI bictegravir with TAF/FTC as a single tablet.
Usage notes
Raltegravir, approved in 2007, was the first. Dolutegravir and bictegravir rarely select for resistance. Long-acting cabotegravir injections are used every one or two months for treatment (with rilpivirine) and for HIV prevention (Apretude, approved in 2021). Weight gain is a recognized side effect, and antacids must be separated from doses.
Related abbreviations
More drug class abbreviations
- HRT – Hormone replacement therapy
- ICI – Immune checkpoint inhibitor
- ICS – Inhaled corticosteroid
- ICS/LABA – Inhaled corticosteroid and long-acting beta-agonist combination
- IMiD – Immunomodulatory imide drug
- INCS – Intranasal corticosteroids
- JAKi – Janus kinase inhibitor
- LABA – Long-acting beta2-agonist
- LABA/LAMA – Long-acting beta-agonist and long-acting muscarinic antagonist…
- LAI – Long-acting injectable
- LAMA – Long-acting muscarinic antagonist
- LMWH – Low-molecular-weight heparin
See all 113 drug class abbreviations →
This entry is for general education and is not medical advice. Abbreviation use varies between institutions; always confirm in context.