FOLFIRINOX
Medical abbreviation · Hematology and Oncology
| Stands for | Folinic acid, fluorouracil, irinotecan, oxaliplatin |
|---|---|
| Categories | Medical |
FOLFIRINOX stands for Folinic acid, fluorouracil, irinotecan, oxaliplatin, a hematology and oncology abbreviation.
Intensive four-drug chemotherapy regimen for pancreatic cancer in patients with good performance status, used for metastatic disease, after surgery and before surgery in borderline resectable disease. It is given every two weeks.
Example: Borderline resectable pancreatic cancer: mFOLFIRINOX x8 cycles, then restaging for surgery.
Usage notes
A 2011 French trial showed median survival of about 11 months versus 7 months with gemcitabine in metastatic pancreatic cancer, and the PRODIGE 24 trial (2018) showed a large survival benefit after surgery. Toxicity is substantial, so a modified version (mFOLFIRINOX) without the fluorouracil bolus is widely used. Growth factor support is often needed.
Related abbreviations
More hematology and oncology abbreviations
- FFP – Fresh frozen plasma
- FISH – Fluorescence in situ hybridization
- FL – Follicular lymphoma
- FLOT – Fluorouracil, leucovorin, oxaliplatin, docetaxel
- FN – Febrile neutropenia
- FOLFIRI – Folinic acid (leucovorin), fluorouracil, irinotecan
- FOLFOX – Folinic acid (leucovorin), fluorouracil, oxaliplatin
- FVL – Factor V Leiden
- G6PD – Glucose-6-phosphate dehydrogenase
- GBM – Glioblastoma multiforme
- GVHD – Graft-versus-host disease
- HbS – Hemoglobin S
See all 144 hematology and oncology abbreviations →
This entry is for general education and is not medical advice. Abbreviation use varies between institutions; always confirm in context.