DPP-4i

Medical abbreviation · Drug Class

DPP-4i
Stands forDipeptidyl peptidase-4 inhibitor
CategoriesMedical

DPP-4i stands for Dipeptidyl peptidase-4 inhibitor, a drug class abbreviation.

Oral diabetes drugs ending in "-gliptin", such as sitagliptin, linagliptin and saxagliptin, that prolong the action of the body's own incretin hormones. They lower blood glucose modestly without weight gain or much hypoglycemia.

Example: Older adult, eGFR 28: linagliptin (DPP-4i) 5 mg daily, no renal adjustment.

Usage notes

Sitagliptin (Januvia), approved in 2006, was the first. Linagliptin is notable for needing no dose change in kidney disease. The FDA has warned about severe joint pain, and the drugs are linked to bullous pemphigoid. They are not combined with GLP-1 receptor agonists because both act on the same pathway.

More drug class abbreviations

  • COC – Combined oral contraceptive
  • COX-2 – Cyclooxygenase-2 selective inhibitor
  • DHP – Dihydropyridine
  • DMARD – Disease-modifying antirheumatic drug
  • DOAC – Direct oral anticoagulant
  • DORA – Dual orexin receptor antagonist
  • DRI – Direct renin inhibitor
  • DTI – Direct thrombin inhibitor
  • EC – Emergency contraception
  • ERA – Endothelin receptor antagonist
  • ERT – Enzyme replacement therapy
  • ESA – Erythropoiesis-stimulating agent

See all 113 drug class abbreviations →

Edited by the AbbreviationList.com team. Spotted an error or a missing meaning? Contact us.

This entry is for general education and is not medical advice. Abbreviation use varies between institutions; always confirm in context.