R-CHOP
Medical abbreviation · Hematology and Oncology
| Stands for | Rituximab, cyclophosphamide, hydroxydaunorubicin (doxorubicin), Oncovin (vincristine), prednisone |
|---|---|
| Categories | Medical |
R-CHOP stands for Rituximab, cyclophosphamide, hydroxydaunorubicin (doxorubicin), Oncovin (vincristine), prednisone, a hematology and oncology abbreviation.
Standard chemoimmunotherapy for diffuse large B-cell lymphoma and other aggressive B-cell lymphomas, usually given every 21 days for six cycles. Prednisone is taken by mouth for five days, while the other drugs are given intravenously.
Example: C3D1 R-CHOP today; neutrophils recovered, pegfilgrastim on day 2.
Usage notes
Adding the anti-CD20 antibody rituximab to CHOP improved survival in a French trial published in 2002, making R-CHOP the standard for two decades; it cures about 60 percent of DLBCL patients. Side effects include low blood counts, nerve damage from vincristine and heart toxicity from doxorubicin. Pola-R-CHP, which substitutes polatuzumab vedotin for vincristine, is used for higher-risk disease.
Related abbreviations
More hematology and oncology abbreviations
- PNH – Paroxysmal nocturnal hemoglobinuria
- PR – Partial response
- PRBC – Packed red blood cells
- PS – Performance status
- PTLD – Post-transplant lymphoproliferative disorder
- PV – Polycythemia vera
- RECIST – Response Evaluation Criteria in Solid Tumors
- RT – Radiation therapy
- SBRT – Stereotactic body radiation therapy
- SCA – Sickle cell anemia
- SCD – Sickle cell disease
- SCLC – Small cell lung cancer
See all 144 hematology and oncology abbreviations →
This entry is for general education and is not medical advice. Abbreviation use varies between institutions; always confirm in context.