P-gp

Medical abbreviation · Pharmacology

P-gp
Stands forP-glycoprotein
CategoriesMedical

P-gp stands for P-glycoprotein, a pharmacology abbreviation.

Transporter protein that pumps drugs out of cells in the gut wall, kidneys, liver and blood-brain barrier, limiting absorption and brain entry. Digoxin, dabigatran and some HIV drugs are P-gp substrates.

Example: Amiodarone inhibits P-gp, so reduce the digoxin dose by about half.

Usage notes

Encoded by the ABCB1 gene (also called MDR1), P-gp was first discovered as a cause of multidrug resistance in cancer cells. Many CYP3A4 inhibitors also block P-gp, which compounds interactions. Some dog breeds, such as collies, carry MDR1 mutations that make ivermectin toxic to them.

More pharmacology abbreviations

  • LD50 – Median lethal dose
  • MOA – Mechanism of action
  • MTD – Maximum tolerated dose
  • NTI – Narrow therapeutic index
  • OIC – Opioid-induced constipation
  • OIH – Opioid-induced hyperalgesia
  • PD – Pharmacodynamics
  • PGx – Pharmacogenomics
  • PIM – Potentially inappropriate medication
  • PK – Pharmacokinetics
  • SAE – Serious adverse event
  • STOPP – Screening Tool of Older Persons' Prescriptions

See all 36 pharmacology abbreviations →

Edited by the AbbreviationList.com team. Spotted an error or a missing meaning? Contact us.

This entry is for general education and is not medical advice. Abbreviation use varies between institutions; always confirm in context.