doxy-PEP
Medical abbreviation · Drug
| Stands for | Doxycycline post-exposure prophylaxis |
|---|---|
| Categories | Medical |
doxy-PEP stands for Doxycycline post-exposure prophylaxis, a drug abbreviation.
Single 200 mg dose of doxycycline taken within 72 hours after condomless sex to prevent bacterial sexually transmitted infections, mainly syphilis and chlamydia, and to a lesser degree gonorrhea.
Example: Offered doxy-PEP: doxycycline 200 mg within 72 h of condomless sex, max once daily.
Usage notes
The CDC issued guidelines in 2024 recommending doxy-PEP for gay and bisexual men and transgender women who had a bacterial STI in the past year, after the DoxyPEP trial showed roughly two-thirds fewer infections. Trials in cisgender women did not show benefit. Concerns include antibiotic resistance, especially in gonorrhea and Staphylococcus aureus.
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This entry is for general education and is not medical advice. Abbreviation use varies between institutions; always confirm in context.