DMF

Science & Engineering abbreviation · Chemistry

DMF
Stands forDimethylformamide
CategoriesScience & Engineering

DMF stands for Dimethylformamide, a chemistry abbreviation.

High-boiling polar aprotic solvent, HCON(CH3)2, used in peptide synthesis, coupling reactions, acrylic fiber spinning and coatings. It dissolves many salts and polymers but is absorbed through skin and is a reproductive toxicant, so its use is restricted in the European Union.

Example: The resin was washed three times with DMF and twice with DCM before cleavage.

Usage notes

The full name is N,N-dimethylformamide. It boils at about 153 °C, which makes it hard to remove, so chemists rely on aqueous workups or high vacuum. EU rules under REACH have limited its use since late 2023 unless worker exposure stays below set limits, encouraging greener substitutes.

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