CNV
Science & Engineering abbreviation · Genetics
| Stands for | Copy-number variation |
|---|---|
| Categories | Science & Engineering |
CNV stands for Copy-number variation, a genetics abbreviation.
Difference between individuals in the number of copies of a DNA segment, typically 1,000 base pairs or longer, caused by deletions or duplications. CNVs can affect whole genes and are a major cause of developmental disorders, as well as normal variation between people.
Example: Chromosomal microarray detected a pathogenic CNV, a deletion at 22q11.2.
Usage notes
Populations with traditionally high-starch diets tend to carry more copies of the salivary amylase gene AMY1, a well-known example of adaptive copy-number variation. CNVs are detected with microarrays or by read depth in sequencing data. Tumors also acquire CNVs, such as amplification of the HER2 gene in some breast cancers.
Related abbreviations
More genetics abbreviations
- BAC – Bacterial artificial chromosome
- BLAST – Basic Local Alignment Search Tool
- bp – Base pair
- cDNA – Complementary DNA
- ChIP-seq – Chromatin immunoprecipitation sequencing
- cM – Centimorgan
- CpG – Cytosine-phosphate-guanine (site)
- dsDNA – Double-stranded DNA
- eQTL – Expression quantitative trait locus
- FISH – Fluorescence in situ hybridization
- GC – Guanine-cytosine (content)
- gDNA – Genomic DNA