OTC

Medical abbreviation · Pharmacy

OTC
Stands forOver-the-counter
CategoriesMedical

OTC stands for Over-the-counter, a pharmacy abbreviation also used in business.

Medicines that can be bought without a prescription, such as acetaminophen, ibuprofen, loratadine and omeprazole 20 mg. In the US, OTC drugs must carry a standardized Drug Facts label listing active ingredients, uses, warnings and directions.

Example: Ask the pharmacist before mixing OTC cold medicines with your blood pressure pills.

Usage notes

The FDA regulates most OTC drugs through monographs, which set allowed ingredients and doses; the 2020 CARES Act modernized that system. Drugs move from prescription to OTC status through "Rx-to-OTC switches", recent examples being naloxone nasal spray and the Opill daily contraceptive, both approved for OTC sale in 2023. In finance, OTC means over-the-counter trading.

More pharmacy abbreviations

  • NF – Non-formulary
  • NS – Normal saline
  • NSS – Normal saline solution
  • ODT – Orally disintegrating tablet
  • oint – Ointment
  • OROS – Osmotic-controlled release oral delivery system
  • P&T – Pharmacy and therapeutics committee
  • PA – Prior authorization
  • PAR – Periodic automatic replenishment
  • PBM – Pharmacy benefit manager
  • PDL – Preferred drug list
  • PDMP – Prescription drug monitoring program

See all 134 pharmacy abbreviations →

This entry is for general education and is not medical advice. Abbreviation use varies between institutions; always confirm in context.